Our updated publication archive | AXXSense https://axxsense.com/category/publication/ Research driven biotechnology platform Thu, 17 Sep 2026 08:44:33 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.5 https://axxsense.com/wp-content/uploads/2024/01/cropped-Axxsense_favicon-1-32x32.png Our updated publication archive | AXXSense https://axxsense.com/category/publication/ 32 32 Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39 https://axxsense.com/vanillin-activates-human-bitter-taste-receptors-tas2r14-tas2r20-and-tas2r39-2/ Thu, 17 Sep 2026 07:44:54 +0000 https://axxsense.com/?p=2423 Frontiers in Nutrition (2021) 8:683627
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L'articolo Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39 proviene da AXXSense.

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Frontiers in Nutrition (2021) 8, 683627

Vanillin, best known for its characteristic vanilla aroma, can also elicit a bitter taste. The identification of TAS2R14, TAS2R20, and TAS2R39 as vanillin-responsive human bitter taste receptors provides new insights into the molecular mechanisms underlying its complex sensory profile.

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L'articolo Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39 proviene da AXXSense.

]]> Bitter taste sensitivity in domestic dogs (Canisfamiliaris) and its relevance to bitterdeterrents of ingestion https://axxsense.com/bitter-taste-sensitivity-in-domestic-dogs-canisfamiliaris-and-its-relevance-to-bitterdeterrents-of-ingestion/ Wed, 16 Sep 2026 15:14:59 +0000 https://axxsense.com/?p=2410 PLOS ONE (2022) 17(11), e0277607
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L'articolo Bitter taste sensitivity in domestic dogs (Canisfamiliaris) and its relevance to bitterdeterrents of ingestion proviene da AXXSense.

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PLOS ONE (2022) 17(11), e0277607

This study reveals key differences in bitter taste sensitivity between domestic dogs and humans. The findings show that canine bitter taste receptors respond differently to specific compounds, including denatonium benzoate, providing insights into bitter taste perception and the effectiveness of bitter deterrents in dogs.

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L'articolo Bitter taste sensitivity in domestic dogs (Canisfamiliaris) and its relevance to bitterdeterrents of ingestion proviene da AXXSense.

]]> Umami taste perception and preferences of the domesticcat (Felis catus), an obligate carnivore https://axxsense.com/umami-taste-perception-cats/ Wed, 16 Sep 2026 08:24:18 +0000 https://axxsense.com/?p=2398 Chemical Senses, (2023) 48
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L'articolo Umami taste perception and preferences of the domesticcat (Felis catus), an obligate carnivore proviene da AXXSense.

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Chemical Senses (2023) 48, bjad026  

This study reveals how the unique characteristics of the feline Tas1r1–Tas1r3 receptor shape umami perception in domestic cats. The findings highlight the importance of nucleotides in enhancing responses to amino acids and provide insight into the taste preferences of cats as obligate carnivores.

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L'articolo Umami taste perception and preferences of the domesticcat (Felis catus), an obligate carnivore proviene da AXXSense.

]]> Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus) https://axxsense.com/kokumi-taste-perception/ Tue, 25 May 2021 17:06:30 +0000 https://axxsense.com/?p=1034 Scientific Reports, (2021) 11:10527
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L'articolo Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus) proviene da AXXSense.

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Scientific Reports, (2021) 11:10527      

Collectively, our data suggest that kokumi is an important taste modality for carnivores that drives the palatability of meat-derived compounds such as amino acids and peptides, and that there are differences in the perception of kokumi taste between carnivores and omnivores.

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L'articolo Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus) proviene da AXXSense.

]]> Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors https://axxsense.com/amidino-rocaglates-a-potent-class-of-eif4a-inhibitors/ Wed, 08 Apr 2020 13:01:09 +0000 https://axxsense.com/?p=511 Cell Chemical Biology Volume 26, Issue 11
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L'articolo Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors proviene da AXXSense.

]]> Cell Chemical Biology
Volume 26, Issue 11, 21 November 2019, Pages 1586-1593

A screen of more than 200 rocaglates identified a novel, potent chemical series, amidino-rocaglates, that target eIF4A1 and eIF4A2 to potently inhibit translation and tumor cell viability, and are effective in synergizing with DNA-damaging agents in vivo against MYC-driven lymphomas. These compounds are promising anti-cancer agents.

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L'articolo Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors proviene da AXXSense.

]]> Glucosinolates in Sisymbrium officinale (L.) Scop. Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter taste receptors https://axxsense.com/glucosinolates-in-sisymbrium-officinale-l-scop-2/ Wed, 01 Apr 2020 16:30:48 +0000 https://axxsense.com/?p=446 Molecules 2019, 24(24), 4572
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L'articolo Glucosinolates in Sisymbrium officinale (L.) Scop. Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter taste receptors proviene da AXXSense.

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The content in glucoputranjivin, which is the chemical marker for glucosinolates in S. officinale, has been determined using high-performance liquid chromatography (HPLC) and a pure reference standard. Glucoputranjivin and two isothiocyanates from S. officinale have been submitted to in vitro assays with the platform of bitter taste receptors of the T2Rs family. The results show that glucoputranjivin is a selective agonist of receptor T2R16.

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L'articolo Glucosinolates in Sisymbrium officinale (L.) Scop. Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter taste receptors proviene da AXXSense.

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