Cell Chemical Biology
Volume 26, Issue 11, 21 November 2019, Pages 1586-1593
A screen of more than 200 rocaglates identified a novel, potent chemical series, amidino-rocaglates, that target eIF4A1 and eIF4A2 to potently inhibit translation and tumor cell viability, and are effective in synergizing with DNA-damaging agents in vivo against MYC-driven lymphomas. These compounds are promising anti-cancer agents.
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